PriCells: Recombinant Human Vascular Endothelial Cell Growth Factor (VEGF)

Human vascular endothelial cell growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells.

The VEGF family currently comprises seven members: VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and PlGF.

Activities of VEGF
(1) Mitogenesis, angiogenesis, and endothelial survival
(2) Effects of VEGF on bone marrow cells and hematopoiesis
(3) Enhancement of vascular permeability and hemodynamic effects

Role of VEGF in Pathological Conditions
(1) Solid tumors
(2) Hematological malignancies
(3) Intraocular neovascular syndromes
(4) Inflammatory disorders and brain edema
(5) Pathology of the female reproductive tract

The VEGF exerts angiogenic, mitogenic and vascular permeability-enhancing activities specific for endothelial cells.

The VEGF has also been shown to be chemotactic for monocytes and osteoblasts.

Purify: 95%, as determined by SDS-PAGE analysis

Species: Human

Activity: ED^₅₀ range = 1-6 ng⁄mL

Specific Activity: 1.0 x 10⁶ - 1.7 x 10⁵ units⁄mg

Bioassay: Proliferation of Human Umbilical Vein Endothelial Cells

Product Size: 1 μg , 10μg, 100μg

Purify Grade: Carrier-Free

Protein Family: Growth Factors

Endotoxin Level: <1EU/ml

Molecular Weight: 40 kDa

Protein Length or portion (a.a): 165 aa

Negative test: HIV-1, HBV, HCV, Mycoplasmas, Bacteria, yeast, and fungus

Protein Form: recombinant human

Expression and Purification: Recombinant Human VEGF is expressed in Human Embryonic Kidney 293 cells and purified via sequential chromatography.

Contents and Storage: Store this lyophilized preparation at -20°C, preferably desiccated. Upon reconstitution, apportioninto working aliquots and store at -20°C. Avoid repeated freeze/thaw cycles.

Expiration Date: Expires one year from date of receipt when stored as instructed.

These products are for research use only and are not intended for human or animal diagnostic, or therapeutic.