PriCells: Recombinant Human Epidermal Growth Factor (rhEGF)

Epidermal growth factor (EGF) is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor.

Human EGF is a 6.0 kDa protein with 53 amino acid residues and three intramolecular disulfide bonds.

The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents.

EGF can be found in human platelets, macrophages, urine, saliva, milk, and plasma.

Because of the increased risk of cancer by EGF, inhibiting it decreases cancer risk.

Purify: 95%, as determined by SDS-PAGE analysis

Species: Human

Bioassay: Proliferation of Human Epidermal Cells

Product Size: 1 μg, 10 μg, 100 μg

Purify Grade: Carrier-Free

Protein Family: Growth Factors

Endotoxin Level: <1EU/ml

Molecular Weight: 6.0 kDa

Protein Length or portion (a.a): 53 aa

Negative test: HIV-1, HBV, HCV, Mycoplasmas, Bacteria, yeast, and fungus

Protein Form: recombinant human

Expression and Purification: Recombinant Human EGF is expressed in E.coli and purified via sequential chromatography.

Contents and Storage: Store this lyophilized preparation at -20°C, preferably desiccated. Upon reconstitution, apportioninto working aliquots and store at -20°C. Avoid repeated freeze/thaw cycles.

Expiration Date: Expires one year from date of receipt when stored as instructed.

These products are for research use only and are not intended for human or animal diagnostic, or therapeutic.